43 Kd protein vaccine and method for the production thereof

Details 43 Kd protein vaccine and method for the production thereof 43 Kd protein vaccine and method for the production thereof

1994-01-25

1999-03-09

Scheiner, Laurie

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

435 71, 435 72, 4242341, G01N 3353, G01N 33569

Patent

active

058799524

ABSTRACT:
A protein derivable from Actinobacillus pleuropneumoniae (APP) having a molecular size ranging between 43 Kd on SDS PAGE is described. The protein is soluble on sodium lauryl sarcosinate (SLS) and not heat modifiable. The protein can also be derived by recombinant methods. The protein in a vaccine provides immunity against multiple serotypes of APP.

REFERENCES:
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Mulks, M., and Thacker, B., in Proc. Int. Pig Veter. Soc. 10 81 (1988).
P. J. Fedorka-Cray, M. J. Huether, D. L. Stine, and G. A. Anderson. Effidacy of a cell extract form Actinobacillus(Haemophilus)pleuropneumoniaeserotype 1 against disease in swine. Infect. Immun. 58:358-365 (1990).
J. Devenish, S. Rosendal, and J. T. Bosse. Humoral antibody response and protective immunity in swine following immunization with the 104 kil-dalton hemolysin of Actinobacillus pleuropneumoniae.Infect. Immuno.58:3829-3832 (1990).
D. K. Lenser, T. L. McDonald, and N. G.Miller. Veter. Microbiol. 18:335-348 (1988).
Sanger, F., et al., PNAS 74:5463-5467 (1977).
Markmeyer, P., et al., Gene 93, 129-134 (1990).

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