43 Kd protein vaccine and method for the production thereof

Details 43 Kd protein vaccine and method for the production thereof 43 Kd protein vaccine and method for the production thereof

1998-01-14

1999-06-15

Scheiner, Laurie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

4241901, 4241921, 4241931, 4241941, 530350, A61K 39385

Patent

active

059119969

ABSTRACT:
A protein derivable from Actinobacillus pleuropneumoniae (APP) having a molecular size ranging between 43 Kd on SDS PAGE is described. The protein is soluble on sodium lauryl sarcosinate (SLS) and not heat modifiable. The protein can also be derived by recombinant methods. The protein in a vaccine provides immunity against multiple serotypes of APP.

REFERENCES:
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J. Devenish, S. Rosendal, and J. T. Bosse, Humoral antibody response and protective immunity in swine following immunization with the 104 kildalton hemolysin of Actinobacillus pleuropneumoniae Infect. Immuno. 58:3829-3832 (1990).
D. K. Lenser, T. L. McDonald, and N. G.Miller. Veter. Microbiol. 18:335-348 (1988).
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Markmeyer, P., et al., Gene 93, 129-134 (1990).
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Young et al., Proc. Natl. Acad. Sci. USA, vol. 80, pp. 1194-1198, Mar. 1983.
Mulks et al., Abstracts of the 91st General Meeting of the American Society for Microbiology, 1991, D-230.
Mierendorf et al., Methods in Enzymology, vol. 152, 1987, pp. 458-469.
Uhlen et al., Methods in Enzymology, vol. 185, 1990, pp. 129-143.
Deneer et al., Vet. Inf. Inf. Dig. Org. Saskatoon, Saskatchewan, Canada, Microbial Pathogenesis, 1989, vol. 6, No. 6, pp. 425-432.

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