Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-08-09
1991-06-11
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
540456, 546 90, A61K 31395, C07D49116
Patent
active
050232630
ABSTRACT:
This invention provides an oxidized derivative of rapamycin in which the hydroxyl at the 42-position has been oxidized to the corresponding ketone or a pharmaceutically acceptable salt thereof, which by virtue of its immunosuppressive and antifungal activity is useful in treating transplantation rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, and fungal infections and a process for the preparation of this oxidized derivative of rapamycin. ##STR1##
REFERENCES:
patent: 3929992 (1975-12-01), Sehgal et al.
patent: 3993749 (1976-11-01), Sehgal et al.
patent: 4316885 (1982-02-01), Rakhit
patent: 4401653 (1983-04-01), Eng
patent: 4650803 (1987-03-01), Stella et al.
patent: 4885171 (1989-12-01), Surendra et al.
J. Antibiot. 28, 721-726 (1975).
J. Antibiot. 28, 727-732 (1975).
J. Antibiot. 31, 539-545 (1978).
Can. J. Physiol. Pharmacol. 55, 48 (1977).
FASEB 3, 3411 (1989).
FASEB 3, 5256 (1989).
Lancet, 1183, (1978).
J. Am. Chem. Soc. 103, 3215 (1981).
Immunology, C.V. Moseby Co., pp. 12.8-12.11 (1989).
American Home Products Corporation
Bond Robert T.
Jackson Richard K.
LandOfFree
42-oxorapamycin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 42-oxorapamycin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 42-oxorapamycin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-782808