4′-thio-L-xylofuranosyl nucleosides, precursors...

Details 4′-thio-L-xylofuranosyl nucleosides, precursors... 4′-thio-L-xylofuranosyl nucleosides, precursors...

2005-07-05

2005-07-05

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S323000, C514S329000, C514S616000, C536S004100, C536S017200, C536S017300, C536S018500, C536S027100, C536S027200, C536S027600, C536S027700, C536S027810, C536S026800, C544S264000, C544S350000, C549S013000, C436S017000

Reexamination Certificate

active

06914061

ABSTRACT:
Compounds represented by the formula 1:A is selected from the group consisting ofwherein each R individually is H or acyl, Y is X, N3, NH2, monoalkylamino, or dialkylamino; Z is O or S; andX is selected from the group consisting of hydrogen, halo, hydroxy, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, thioaryl, thioalkyl, allylamino, cyano and nitro; tautomers thereof; and pharmaceutically acceptable salts thereof are provided along with methods for their fabrication. Various of these compounds can be used as anticancer agents, or antiviral agents or to inhibit DNA replication.

REFERENCES:
patent: 6252061 (2001-06-01), Sampath et al.
patent: 6596858 (2003-07-01), Sampath et al.
Secrist III et al., “Synthesis and biological activity of certain 4′-thio-D-arabinofuranosylpurine nucleosides.” J. Med. Chem. 41, pp. 3865-3871, 1998.
Hartsel et al., “Synthesis of (-(4-thioxylofuranosyl)adenine via a novel glycosylation reaction.” Tetrahedron Letters, 39, pp. 205-208, 1998.

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