4′-substituted nucleoside derivatives as inhibitors...

Details 4′-substituted nucleoside derivatives as inhibitors... 4′-substituted nucleoside derivatives as inhibitors...

2011-03-29

2011-03-29

Crane, Lawrence E (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S046000, C514S047000, C514S048000, C536S026230, C536S026260, C536S026700, C536S027210, C536S027600, C536S027610, C536S027620, C536S027800, C536S027810

Reexamination Certificate

active

07915232

ABSTRACT:
The present invention relates to the use of nucleoside derivatives of formula Iawherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof which inhibit HCV polymerase and are useful for treating a patient suffering from a HCV infection and to pharmaceutical compositions containing such compounds.

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patent: WO98/16184 (1998-04-01), None
Hai et al. (I), Species- or Isozyme-Specific Enzyme Inhibitors. 9. Selective Effects in Inhibitions of Rat Pyruvate Kinase Isozymes by Adenosine 5′-Diphosphate Derivatives, Journal of Medicinal Chemistry, 25(10), 1184-1188 (1982).
Hai et al. (II), Species- or Isozyme-Specific Enzyme Inhibitors. 7. Selective Effects in Inhibitions of Rat Pyruvate Kinase Isozymes by Adenosine 5′-Diphosphate Derivatives, Journal of Medicinal Chemistry, 25(7), 806-812 (1982).
Hans Maag, et al., “Synthesis and Anti-HIV Activity of 4′-Azido- and 4′-Methoxynucleosides1”,Journal of Med. Chem., (1992), pp. 1440-1451, vol. 35.
J. G. Moffatt, outline of the synthesis of 4′-azidocytidine from chapter titled “Chemical Transformations of the Sugar Moiety of Nucleosides,” from bookNucleoside Analogues, (1979) p. 144 published by Plenum Press, New York and London.

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