4-Ureido-2-acyl phenoxypropanolamine

Details 4-Ureido-2-acyl phenoxypropanolamine 4-Ureido-2-acyl phenoxypropanolamine

1974-12-17

1977-07-05

Wyman, Daniel E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260244R, 260250A, 2602564H, 26029377, 2603264, 260465D, 26050117, 260553C, 424250, 424251, 424267, 424274, 424304, 424316, 424322, 42424854, 424230, C07C12715, C07C12719, A61K 3117

Patent

active

040340090

ABSTRACT:
Phenoxypropylamine derivatives of the general formula: ##STR1## in which R is a hydrogen atom or a straight-chain or branched alkyl group containing up to 10 carbon atoms, R.sub.1 is a hydrogen atom, a straight-chain or branched alkyl group containing up to 10 C atoms or a cyclopentyl, cyclohexyl, benzyl or phenyl group or R and R.sub.1 taken together form a pentamethylene-(1,5), tetramethylene-(1,4), 2-azapentamethylene-(1,5), 3-azapentamethylene-(1,5) and 3-oxapentamethylene-(1,5)-group, R.sub.2 is an alkyl group containing up to 6 carbon atoms or a benzyl or phenyl group and R.sub.3 is a branched alkyl group containing 3 to 6 carbon atoms, a cyanoalkyl group containing up to 6 carbon atoms or a cycloalkyl group containing 3 to 7 carbon atoms, and pharmaceutically-acceptable salts thereof, having a cardio-selective .beta.-blocking action.

REFERENCES:
patent: 3644520 (1972-02-01), Hartley et al.
patent: 3925446 (1975-12-01), Koppe et al.
patent: 3928412 (1975-12-01), Smith
patent: 3930016 (1975-12-01), Berntsson et al.
patent: 3935259 (1976-01-01), Wilhelm
patent: 3944611 (1976-03-01), Smith
patent: 3959369 (1976-05-01), Smith
patent: 3983169 (1976-09-01), Zolss et al.
patent: 3998790 (1976-12-01), Brandstrom et al.
Smith, CA 80:27003s (effective date 11/15/73).
Danilewicz et al., CA 74:99680j (1971).
Smith, CA 78:71716j (1973).
Wilhelm, CA 76:140273k (1972).

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