4-Trifluoromethylbenzoic acid derivatives as thromboembolic agen

Details 4-Trifluoromethylbenzoic acid derivatives as thromboembolic agen 4-Trifluoromethylbenzoic acid derivatives as thromboembolic agen

1976-06-10

1978-06-20

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

260521H, 560143, A61K 3160

Patent

active

040962520

ABSTRACT:
2-OR-4-trifluoromethylbenzoic acid wherein R is H or acyl.
The compounds are useful in the treatment of pathological cardiovascular conditions, particularly in the prophylaxis of the thromboembolic diseases.
The compounds are made by reacting m-trifluoromethyl phenol with potassium carbonate and carbon dioxide at an elevated temperature and pressure and, if desired, acetylating the 2-OH compound thus obtained or reacting it with a phosphonating agent.
The invention also embraces pharmaceutical compositions in which the compounds constitute the effective agent and a method of treatment.

REFERENCES:
patent: 3019253 (1962-01-01), Hauptschein

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