4-Tertiary-amino-2,6-diaminopyridine 1-oxides

Details 4-Tertiary-amino-2,6-diaminopyridine 1-oxides 4-Tertiary-amino-2,6-diaminopyridine 1-oxides

1978-01-30

1980-01-08

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546281, 546308, 546306, 546271, 546199, 546116, 544131, 544 60, 544360, 544 82, 424246, 42424856, 424267, 424263, 424250, C07D40112

Patent

active

041828887

ABSTRACT:
A series of 2,6-diamino-4-tertiary-amino-pyridine 1-oxides is disclosed. Substituents in the 4-position include diethylamino, pyrrolidinyl, piperidino, morpholino, thiomorpholino, and N-methylpiperazino. Novel oxadiazolones such as 5-amino-7-(1-piperidinyl)-2H-[1,2,4]-oxadiazolo[2,3-a]pyridine-2-one which are useful in the preparation of the pyridine 1-oxides are also disclosed. The compounds of this invention lower blood pressure in normotensive and hypertensive mammals and are particularly useful in the treatment of hypertensive conditions in mammals. 2,6-Diamino-4-(1-piperidinyl)pyridine 1-oxides is a prepresentative embodiment of the invention.

REFERENCES:
patent: 3329569 (1967-07-01), Tedeschi et al.
patent: 3382248 (1968-05-01), Anthony et al.
patent: 4021562 (1977-05-01), Lawson et al.
patent: 4080500 (1978-03-01), Lawson et al.
Chemical Abstracts, vol. 35, p. 7965 col. 2 (1941), Abstracting E. Ochiai et al.

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