4-Tertiary-amino-2,6-diaminopyridine 1-oxides

Details 4-Tertiary-amino-2,6-diaminopyridine 1-oxides 4-Tertiary-amino-2,6-diaminopyridine 1-oxides

1977-02-28

1978-03-21

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

260268H, 544 60, C07D40104, C07D41304, C07D41704

Patent

active

040805000

ABSTRACT:
A series of 2,6-diamino-4-tertiary-amino-pyridine 1-oxides is disclosed. Substituents in the 4-position include diethylamino, pyrrolidinyl, piperidino, morpholino, thiomorpholino, and N-methyl-piperazino. Novel oxadiazolones such as 5-amino-7-(1-piperidinyl)-2H-[1,2,4]-oxadiazolo[2,3-a]pyridine-2-one which are useful in the preparation of the pyridine 1-oxides are also disclosed. The compounds of this invention lower blood pressure in normotensive and hypertensive mammals and are particularly useful in the treatment of hypertensive conditions in mammals. 2,6-Diamino-4-(1-piperidinyl)pyridine 1-oxide is a representative embodiment of the invention.

REFERENCES:
patent: 3329569 (1967-07-01), Tedeschi et al.
patent: 3382248 (1968-05-01), Anthony et al.
patent: 4021562 (1977-05-01), Lawson et al.
Ochiai et al. "Chem. Abstracts" vol. 35 (1941), p. 7965.sup.2.

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