4-Tertiary-amino-2,6-diaminopyridine 1-oxides

Details 4-Tertiary-amino-2,6-diaminopyridine 1-oxides 4-Tertiary-amino-2,6-diaminopyridine 1-oxides

1979-08-23

1981-10-27

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546187, 546193, 546281, 546306, 544 82, 544124, 544127, 544360, 544357, 544362, 544 584, 544 586, 424246, 42424854, 42424856, 424250, 424256, 424263, 424267, 544 60, 546308, 544 61, 544125, 544361, C07D41112, C07D49804, C07D40112

Patent

active

042974984

ABSTRACT:
A series of 2,6-diamino-4-tertiary-amino-pyridine 1-oxides is disclosed. Substituents in the 4-position include diethylamino, pyrrolidinyl, piperidino, morpholino, thiomorpholino, and N-methylpiperazino. Novel oxadiazolones such as 5-amino-7-(1-piperidinyl)-2H-[1,2,4]oxadiazolo[2,3-a]pyridine-2-one which are useful in the preparation of the pyridine 1-oxides are also disclosed. The compounds of this invention lower blood pressure in normotensive and hypertensive mammals and are particularly useful in the treatment of hypertensive conditions in mammals. 2,6-Diamino-4-(1-piperidinyl)pyridine 1-oxide is a representative embodiment of the invention.

REFERENCES:
patent: 3329569 (1976-07-01), Tedeschi et al.
patent: 3882248 (1968-05-01), Anthony et al.
patent: 4021562 (1977-05-01), Lawson et al.
patent: 4080500 (1978-03-01), Lawson et al.
Chemical Abstracts, vol. 35 (1941) p. 7965.sup.2 abstracting Ochiai et al., in J. Pharm. Soc. Japan, vol. 61, pp. 107-108, Abstracts (in German) pp. 52-41 (1941).

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