4-substituted quinoline derivatives, method and...

Details 4-substituted quinoline derivatives, method and... 4-substituted quinoline derivatives, method and...

2008-03-25

2008-03-25

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

10913222

ABSTRACT:
The invention relates to 4-substituted quinoline derivatives of general formula:which are active as antimicrobials, in which:X1, X2, X3, X4and X5represent >C—R′1to >C—R′5respectively, or alternatively at most one represents nitrogen,Y represents CHR, CO, CROH, CRNH2, CRF or CF2, R being a hydrogen or alkyl, m is 0, 1 or 2 and n is 0 or 1, R2represents a radical R, —CO2R, —CH2CO2R, —CH2—CH2CO2R, —CONH2, —CH2—CONH2, —CH2—CH2—CONH2, —CH2OH, —CH2—CH2OH, —CH2—NH2—CH2—CH2—NH2or —CH2—CH2—CH2—NH2, R being as defined above,R3represents phenyl, heteroaryl or alk-Ro3, where alk is alkyl and Ro3represents various groups, where appropriate containing oxygen, sulfur or amine, in their enantiomeric or diastereoisomeric forms or their mixtures, and/or where appropriate in the syn or anti form or their mixtures, and their salts.

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