4-substituted quinoline derivatives, method and...

Details 4-substituted quinoline derivatives, method and... 4-substituted quinoline derivatives, method and...

2007-06-19

2007-06-19

Dentz, Bernard (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S266100, C514S303000, C514S249000, C514S235200, C546S122000, C546S174000, C544S128000, C544S235000, C544S284000

Reexamination Certificate

active

10810711

ABSTRACT:
The invention relates to 4-substituted quinoline compounds of general formula:which are active as antimicrobials, in which:X1, X2, X3, X4and X5is C—R′1, to C—R′5respectively, or alternatively at most one represents N,Y represents CHR, CO, CROH, CRNH2, CRF or CF2, R being a hydrogen or alkyl, m is 1, 2 or 3 and n is 0, 1 or 2, Z is CH2or Z is O, S, SO, SO2and, in this case, n is equal to 2, R2is —CO2R, —CH2CO2R, —CH2—CH2CO2R, —CH2OH or —CH2—CH2OH,wherein R is as defined above,R3represents phenyl, heteroaryl or alk-Ro3, where alk is alkyl and Ro3represents various groups, where appropriate containing oxygen, sulfur or amine, in their enantiomeric or diastereoisomeric forms or their mixtures, and/or where appropriate in the syn or anti form or their mixtures, and their salts.

REFERENCES:
patent: 2004/0147518 (2004-07-01), Bacque et al.
patent: 2816618 (2002-05-01), None
patent: WO 01/07432 (2001-02-01), None

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