4-(Substituted phenyl thiazolyl)-3-hydroxy-3-pyrroline-2,5-dione

Details 4-(Substituted phenyl thiazolyl)-3-hydroxy-3-pyrroline-2,5-dione 4-(Substituted phenyl thiazolyl)-3-hydroxy-3-pyrroline-2,5-dione

1979-09-11

1981-11-03

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424270, C07D41704, A61K 31425

Patent

active

042987431

ABSTRACT:
Novel 4-(substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate renal lithiasis.

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Liao et al., Arch. Biochem. Biophys., 154, pp. 68-75 (1973).
Harlay, J. Pharm. Chim., 24, pp. 537-548 (1936).
Randall et al., J. Med. Chem., 22, pp. 608-614 (1979).
G. S. Skinner et al., J. Am. Chem. Soc., 73, pp. 2230-2233 (1951).
G. S. Skinner et al., J. Am. Chem. Soc., 70, pp. 4011-4013 (1948).

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