Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-06-12
2007-06-12
Coleman, Brenda (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S211150, C540S544000
Reexamination Certificate
active
10834301
ABSTRACT:
The present invention relates to novel, low molecular weight broad spectrum compounds in particular to a class of 4-substituted or unsubstituted-7-hydro-1,4-thiazepine-7-[bicyclic or tricyclic heteroaryl] substituted-3,6-dicarboxylic acid or their derivatives which have β-lactamase inhibitory and antibacterial properties. The compounds are therefore useful in the treatment of antibacterial infections in humans or animals, either alone or in combination with other antibiotics.
REFERENCES:
patent: WO 00/05246 (2000-02-01), None
Nigel J.P. Broom, et al., Studies of the Mechanism of Action (5R)-(Z)-6-(1-Methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic Acid (BRL 42715), a Potent Inhibitor of Bacterial β-Lactamase,J. Chem. Soc., Chem. Communication, 1992, 1663-1664.
Giuseppina Visentin, et al., Δ3-Thiazolines Δ4-Thiazolines and Thiazoles from Penem Antibiotics,Heterocycles, vol. 33, No. 2, 859-891, 1992.
Keiko Tabei, et al., Mechanism of Inactivation of β-Lactamases by Novel 6-Methylidene Penems Elucidated Using Electrospray Ionization Mass Spectrometry,J. Med. Chem. 2004, 47, 3674-3688.
Michiyoshi Nukaga, et al., Inhibition of Class A and Class C β-Lactamases by Penems: Crystallographic Structures of a Novel 1,4-Thiazepine Intermediate,Biochemistry2003, 42, 13152-13159.
Mansour Tarek Suhayl
Venkatesan Aranapakam Mudumbai
Coleman Brenda
Hogan Jr. John W.
Wyeth Holdings Corporation
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