4-(substituted-isoindol-2-yl)phenoxy-pentanoic and -heptanoic ac

Details 4-(substituted-isoindol-2-yl)phenoxy-pentanoic and -heptanoic ac 4-(substituted-isoindol-2-yl)phenoxy-pentanoic and -heptanoic ac

1986-10-27

1988-04-12

Ceperley, Mary E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514421, 548476, 548513, A61K 3140, C07D20948

Patent

active

047375124

ABSTRACT:
Novel 4-(substituted-isoindol-2-yl)phenoxy-pentanoic and -heptanoic acids and derivatives which are useful as anti-arteriosclerotic agents are disclosed. The compounds elevate the high density lipoprotein fraction of cholesterol and also lower the low density lipoprotein fraction of cholesterol. Methods for preparing and using the compounds are included.

REFERENCES:
patent: 3804839 (1974-04-01), Dahm et al.
patent: 3978080 (1976-08-01), Carney
Derwent Abstract of Great Britain Patent No. 2,082,569 published Mar. 10, 1982.
Derwent Abstract of Japanese Patent No. 45 6115773, published Sep. 11, 1981.
M. Artico et al., Biochem. Pharmacology, vol. 17, pp. 893-898 (1968).
American Journal of Medicine, vol. 62, pp. 707-714, Gordon, T. et al., High Density Lipoprotein as a Protective Factor Against Coronary Heart Disease, May '77.
Jama 251:361 and 365 (1984).
Journal of Medicinal Chemistry, 1985, vol. 28, No. 1 pp. 10-12 Comparison of the Hypolipidemic Activity of Cyclic vs. Acyclic Imides, P. Josee Voorstad, et al.

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