4-Substituted enkephalin derivatives

Details 4-Substituted enkephalin derivatives 4-Substituted enkephalin derivatives

1976-08-09

1978-05-30

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

040923045

ABSTRACT:
Analogs of methionine.sup.5 -enkephalin and leucine.sup.5 -enkephalin wherein the L-phenylalanyl residue in position 4 has been substituted by various other amino acid residues are disclosed herein. These analogs exhibit agonist activity at opiate receptor sites and are thus useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.

REFERENCES:
patent: 3272790 (1966-09-01), Bernardi et al.
Li, et al; Nature, 260, 1976, p. 624.
A. Waterfield, et al; Nature, 260, 1976, p. 625.
J. Hughes, et al; Nature, 258, 1975, pp. 577-579.
A. Day, et al; Chem. Abst., 85, 1976, 117055t.
W. Voelter, et al; Tet. Let. 25, 2119-2120, 1976.

Affiliated with

Also associated with

Rating

4-Substituted enkephalin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-Substituted enkephalin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-Substituted enkephalin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-468935