4-(substituted cycloalkylmethyl) imidazole-2-thiones,...

Details 4-(substituted cycloalkylmethyl) imidazole-2-thiones,... 4-(substituted cycloalkylmethyl) imidazole-2-thiones,...

2006-03-09

2008-09-02

Shameem, Golam M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S300100, C548S316400, C548S325100, C514S385000, C514S386000

Reexamination Certificate

active

07419994

ABSTRACT:
Compounds of Formula 1where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2Band/or alpha2Cadrenergic receptors in preference over alpha2Aadrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2Badrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.

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