4-(substituted cycloalkylmethyl) imidazole-2-thiones,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S300100, C548S316400, C548S323500, C514S385000, C514S396000, C514S398000

Reexamination Certificate

active

07345077

ABSTRACT:
Compounds of Formula 1where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2Band/or alpha2Cadrenergic receptors in preference over alpha2Aadrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2Badrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.

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