Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-08-08
2000-07-25
Huang, Evelyn Mei
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514212, 5142282, 5142328, 514249, 514254, 514291, 540483, 540597, 544 60, 544126, 544353, 544405, 546 80, 546 85, 546 86, 546 87, 546 89, A61K 3144, A61K 31535, C07D47104
Patent
active
060937238
ABSTRACT:
This invention relates to 4-substituted .beta.-carbolines and .beta.-carboline analogs that inhibit Ca.sup.+2 influx and interleukin-2 (IL-2) production. The 4-substituted .beta.-carbolines and .beta.-carboline analogs of this invention are represented by formula (I): ##STR1## wherein Q, n, R, R', R" and R.sub.1 -R.sub.4 are as defined herein. This invention also relates to methods for producing .beta.-carbolines. Because of their selective immunomodulating properties, the compounds and pharmaceutical compositions of this invention are particularly well suited for preventing and treating immune disorders, including autoimmune disease, inflammatory disease, organ transplant rejection and other disorders associated with IL-2 mediated immune response.
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Hargrave Karl D.
Miao Clara K
Parks Thomas P.
Potocki Ian F.
Snow Roger J.
Boehringer Ingelheim Pharmaceuticals Inc.
Bottino Anthony P.
Huang Evelyn Mei
Raymond Robert P.
Stempel Alan R.
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