[4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-

Details [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3- [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-

1985-05-29

1986-11-18

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540481, 540599, 514224, 544 49, 544 62, 544107, 544124, 544130, 544141, 544145, 544147, 544168, 544376, 546256, 546270, 546275, 546283, 546284, C07D41710, C07D27916, A61K 3154

Patent

active

046234861

ABSTRACT:
Certain novel p-aminomethylbenzoyl derivatives of 4-hydroxy-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide and several other closely-related known oxicams have been prepared. These particular compounds are useful in therapy as prodrug forms of the known anti-inflammatory and analgesic oxicams. Preferred member compounds include 2-methyl-4-[4-(morpholinomethyl)benzoyloxy]-N-(2-pyridinyl)-2H-1,2-benzoth iazine-3-carboxamide 1,1-dioxide, 2-methyl-4-[4-(piperidinomethyl)benzoyloxy]-N-(2-pyridinyl)-2H-1,2-benzoth iazine-3-carboxamide 1,1-dioxide, 2-methyl-N-(6-methyl-2-pyridinyl)-4-[4-(piperidinomethyl)benzoyloxy]-2H-1, 2-benzothiazine-3-carboxamide 1,1-dioxide, 2-methyl-4-[4-(4-methylpiperazinomethyl)benzoyloxy]-N-(2-pyridinyl)-2H-1,2 -benzothiazine-3-carboxamide 1,1-dioxide and 2-methyl-4-[4-(pyridiniummethyl)benzoyloxy]-N-(2-pyridinyl)-2H-1,2-benzoth iazine-3-carboxamide 1,1-dioxide chloride. Methods for preparing these compounds from known starting materials are provided.

REFERENCES:
patent: 3591584 (1971-07-01), Lombardino
patent: 3788324 (1974-01-01), Zinnes et al.
patent: 3822258 (1984-07-01), Zinnes et al.
patent: 3900470 (1975-08-01), Rasmussen
patent: 3925371 (1975-12-01), Rasmussen
patent: 4180662 (1979-12-01), Pfister et al.
patent: 4309427 (1981-01-01), Lombardino
patent: 4376768 (1983-03-01), Ozaki et al.
patent: 4434164 (1984-02-01), Lombardino
patent: 4461768 (1984-07-01), Dell'Acqua et al.
patent: 4540692 (1985-09-01), Ueda et al.
patent: 4551452 (1985-11-01), Marfat
J. G. Lombardino et al., "Potent Antiinflammatory N-Heterocyclic _3-Carboxamides of 4-Hydroxy-2-Methyl-2H-1,2-Benzothiazine 1,1-Dioxide", Journal of Medicinal Chemistry, vol 16, No. 5, p. 493 (1973).

Affiliated with

Also associated with

Rating

[4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3- does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3- will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1616470