4-substituted benzopyran and related compounds

Details 4-substituted benzopyran and related compounds 4-substituted benzopyran and related compounds

1993-05-12

1995-02-28

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514457, 5483051, 549404, A61K 3135, C07D31168, C07D40504, C07D40512

Patent

active

053937716

ABSTRACT:
Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof. These compounds have potassium channel activating activity and are useful, therefore for example, as cardiovascular agents.

REFERENCES:
patent: 3933847 (1976-01-01), Ohkawa et al.
patent: 4238501 (1980-12-01), Kabbe et al.
patent: 4575511 (1986-03-01), Evans et al.
patent: 4764622 (1988-08-01), Claussen et al.
patent: 4988723 (1991-01-01), Shiokawa et al.
patent: 5028711 (1986-03-01), Stenzel et al.
patent: 5082858 (1992-01-01), Garcia et al.
patent: 5096914 (1992-03-01), Stenzel et al.
patent: 5140031 (1992-08-01), Atwal et al.
H. J. Petersen et al., "Synthesis and Hypotensive Activity of N-Alkyl-N"-cyano-N'-pyridylguanidines", J. of Med. Chem., vol. 21, No. 8, (Aug. 1978), pp. 773-781.
V. A. Ashwood et al., "Synethsis and Antihypertensive Activity of 4-(Cyclic amido)-2H-1-benzopyrans", J. Med. Chem., (1986), 29, 2194-2201.
C. R. Rasmussen et al., "Improved Procedures for the Preparation of Cycloalkyl-, Arylalkyl-, and Arylthioureas", Synthesis, (Jun. 1988), pp. 456-459.
V. V. Mozolis et al., "Preparation of N-Substituted Thiourea", Russian Chem. Reviews, 42(7), (1973), pp. 587-595.
J. M. Evans et al., "Synthesis and Antihypertensive Activity of Substituted trans-4-Amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols", J. Med. Chem., (1983), 26, pp. 1582-1589.
R. W. Lang et al., "Synthesis of Selectively Trifluoromethylated Pyridine Derivatives as Potential Antihypertensives", Helvetica Chimica Acta, (1988), vol. 71, pp. 596-601.
P. Sebok et al., "Selective syknthesis of Analogues of the Natural Precocenes, Synthesis and Regioselective (-Alkylation of 6-Chloro- and 6-Tert-Butyl-7,8-Dihyedroxy-2,2-Dimethyl-4-Chromanones", Heterocycles, (1988), 27, pp. 2595-2607.
P. Teixidor et al., "Improved Preparation of Precocene II, Unexpected Results in the Reduction of Alkoxy Substituted Acetophenones and 4-Chromanones with Sodium Borohydride", Heterocycles, (1988), 27, pp. 2459-2465.
A. Banerji et al., "Enolates of o-Hydroxyacetophenones: Novel Syknthesis of 2,2-Dialkyl-4-Chromanones", Tetrahedron Letters, No. 38, 1979, pp. 3685-3686.
G. Ariamala et al., "A Simple Route for the Synthesis of 4-Chlorochromenes and Chroman-4-ones", Tetrahydron Letters, (1988), vol. 29, No. 28, pp. 3487-3488.

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