4-substituted azetidinones as precursors to 2-substituted-3-carb

Details 4-substituted azetidinones as precursors to 2-substituted-3-carb 4-substituted azetidinones as precursors to 2-substituted-3-carb

1991-03-20

1993-02-23

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540350, C07D48700, C07D48704

Patent

active

051891581

ABSTRACT:
New 4-substituted azetidinones having the formulea I and II: ##STR1## with R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and X defined hereafter, which are intermediates for the preparation of carbapenem and carbacephem antibacterials and processes for producing such antibacterials through the utilization of an acid mediated ring closure reaction.

REFERENCES:
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patent: 5055573 (1991-10-01), Cama et al.
patent: 5064954 (1991-11-01), Uyei et al.
patent: 5068232 (1991-11-01), Ziegler et al.
patent: 5122604 (1992-06-01), Sunagawa et al.
March, Jerry, Advanced Organic Chemistry, John Wiley Sons, U.S.A., 1985 pp. 796-798.
Wasserman et al., Tetrahedron Letters, 25: 3747-3750 (1984).

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