4-Substituted amino-.alpha.-aminomethylbenzyl alcohol derivative

Details 4-Substituted amino-.alpha.-aminomethylbenzyl alcohol derivative 4-Substituted amino-.alpha.-aminomethylbenzyl alcohol derivative

1976-01-23

1977-12-13

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260553A, 2605706, 424300, 424322, 424330, C07C12506

Patent

active

040630250

ABSTRACT:
There are disclosed novel 4-substituted amino-.alpha.-aminomethylbenzyl alcohol derivatives represented by the formula: ##STR1## wherein X represents a halogen atom; Y represents a hydrogen atom or a halogen atom; R.sub.1 represents a lower alkyl group, a carbamoyl group, a mono- or di-lower alkyl-substituted carbamoyl group, a phenyl-substituted carbamoyl group, a lower alkoxycarbonyl group, a lower alkoxy-substituted lower alkoxycarbonyl group, a phenyl-substituted lower alkoxycarbonyl group, or a cycloalkyloxycarbonyl group; and R.sub.2 represents a lower alkyl group, a cycloalkyl group, or the group shown by the formula ##STR2## wherein R.sub.3 represents a hydrogen atom or a lower alkyl group and R.sub.4 represents a hydrogen atom, a hydroxy group, or a lower alkoxy group and the pharmaceutically acceptable nontoxic salts thereof.
These compounds are antiasthmatic agents useful for the prophylaxis and treatment of asthma.

REFERENCES:
patent: 2734911 (1956-02-01), Strain
patent: 3577453 (1971-05-01), Rohr et al.
patent: 3657319 (1972-04-01), Kaiser et al.
patent: 3721699 (1973-03-01), Traber et al.

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