4-Substituted-5-cyano-1H-pyrimidin-6-(thi)ones as GSK-3...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S269000, C544S122000, C544S123000, C544S319000

Reexamination Certificate

active

10799507

ABSTRACT:
The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various GSK-3-mediated disorders, such as diabetes and Alzheimer's disease.

REFERENCES:
patent: 1 074 549 (2003-11-01), None
patent: WO 01/70728 (2001-09-01), None
patent: WO 02/096905 (2002-12-01), None
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Gary W. Cline et al, “Effects of a Novel Glycogen Synthase Kinase-3 Inhibitor on Insulin-Stimulated Glucose Metabolism in Zucker Diabetic Fatty(fa/fa) Rats”, Diabetes, 51: 2903-2910 (2002).
Erik J. Henriksen et al, “Modulation of Muscle Insulin Resistance by Selective Inhibition of GSK-3 in Zucker Diabetic Fatty Rats”, American Journal of Physiology Endocrinology and Metabolism, 284: E892-E900 (2003).

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