Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-11-13
2000-02-01
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546225, 546226, 546227, 546228, 546231, 514317, A01N 4340, C07D21130, C07D21160, C07D21126
Patent
active
060203471
ABSTRACT:
4-Substituted-4-piperidinecarboxamides of Formula I are antagonists of VLA-4 and/or .alpha..sub.4 .beta..sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.
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CA 123: 285788 Abstract, Ookubo Mitsuru et al, Formula II.
deLaszlo Stephen E.
Hagmann William K.
Desai Rita
Merck & Co. , Inc.
Rose David L.
Rotman Alan L.
Yang Mollie M.
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