4-substituted-4-piperidine carboxamide derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546225, 546226, 546227, 546228, 546231, 514317, A01N 4340, C07D21130, C07D21160, C07D21126

Patent

active

060203471

ABSTRACT:
4-Substituted-4-piperidinecarboxamides of Formula I are antagonists of VLA-4 and/or .alpha..sub.4 .beta..sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.

REFERENCES:
patent: 5510332 (1996-04-01), Kogan et al.
patent: 5770575 (1998-06-01), Beavers et al.
Shroff, Hitesh N., Bioorganic & Medicinal Chemistry Letters vol. 6, No. 21 pp. 2495-2500 (1996).
Jackson, David Y. et als. Med. Chem., 40 pp. 3359-3368 (1997).
CA 129: 81969 Abstract, Beavers et al RN # 173299-59-7, 173051-59-7.
CA: 114:247788 Abstract, Kempf Dale et al RN # 129739-41-9.
CA 128: 13215 Abstract, Costanzo Michael et al. RN #198959-13-6.
CA 126:47110 Abstract, Ookubo Mitsuru et al RN # 184715-74-0, 184715-75-1.
CA 123: 285788 Abstract, Ookubo Mitsuru et al, Formula II.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

4-substituted-4-piperidine carboxamide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-substituted-4-piperidine carboxamide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-substituted-4-piperidine carboxamide derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-937807

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.