4'-Substituted-4,5',8-trialkylpsoralens

Details 4'-Substituted-4,5',8-trialkylpsoralens 4'-Substituted-4,5',8-trialkylpsoralens

1979-09-10

1981-05-26

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Synthetic or structurally-modified peptidoglycan or...

26034321, C07D49304, A61K 31365

Patent

active

042698529

ABSTRACT:
The invention relates to 4,5',8-trialkylpsoralens, having a substituent on the 4' carbon atom which is selected from hydroxyalkoxyalkyl and hydroxyalkylaminoalkyl, which are characterized by enhanced photosensitizing activity, especially oral activity, including comparable maxima, early onset, and especially rapid decline, as well as low toxicity, when contrasted with psoralens of different structure.

REFERENCES:
patent: 4124598 (1978-11-01), Hearst et al.
patent: 4169204 (1979-09-01), Hearst et al.
Hearst et al., (II) Chem. Abst. 87:78962f, 1977.
Dawber, J. Soc. Comet. Chem. 28-403 to 406, 1977.
Martins et al., Chem. Abst., vol. 81, 1974, 99676g.
Shen et al., Chem. Abst., vol. 88, 59494j.
Johnston et al., Chem. Abst., 87:147284a.
Isaacs et al., Chem. Abst., 86:135108n.

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