Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1979-11-05
1982-08-03
Springer, David B.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
2603265C, A61K 3140, C07D207416
Patent
active
043427766
ABSTRACT:
Novel 4-substituted-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate kidney stone formation. A novel process for their preparation is also disclosed.
REFERENCES:
patent: 3340263 (1967-09-01), Stachelln et al.
Liao et al., Arch. Biochem. Biophys., 154, pp. 68-75 (1973).
Harlay, J. Pharm. Chim., 24, pp. 537-548 (1936).
Randall et al., J. Med. Chem., 22, pp. 608-614 (1979).
G. S. Skinner et al., J. Am. Chem. Soc., 73, pp. 2230-2233 (1951) and 70, pp. 4011-4013 (1948).
Cragoe, Jr. Edward J.
Rooney Clarence S.
Williams Haydn W. R.
Merck & Co. , Inc.
Speer Raymond M.
Springer David B.
Sudol, Jr. Michael C.
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