4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin

Details 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin

1997-09-22

1999-06-29

Berch, Mark L

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540355, 540357, 540359, 540360, A61K 31395, C07D205085, C07D205095

Patent

active

059168870

ABSTRACT:
In accordance with the present invention, there are provided 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives of the formula: ##STR1## wherein n is 1, 2 or 3; in which R.sub.1, R.sub.2 and R.sub.3 are as defined herein, and salts thereof, which exhibit excellent cysteine proteinase inhibitory activity and which can be used for treatment of different diseases such as muscular dystrophy, myocardial infarction, bone resorption, arthritis, cancer metastasis, pulmonary emphysema, septic shock, cerebral ischemia, memory function, Alzheimer and cataract, malaria, glomerular basement membrane degradation, bacterial infection, inflammatory diseases, parasitic infections, and viral infections.

REFERENCES:
Jewell, Biochemistry 31, 7862-9, 1992.
Thomas, Biochimica et Biophysica Acta 990, 246-253, 1989.
Wang, TiPs 15, p. 412, Nov. 1994.
Otto, Chemical Reviews 97, 133-171, 1997.

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