Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus acids or salts thereof
Patent
1992-03-16
1994-03-15
Dees, JoseG.
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus acids or salts thereof
514114, 560 39, 560110, 560169, 560170, C07F 938, A61K 3166
Patent
active
052947343
ABSTRACT:
Substituted 2-aminoalk-3-enoic acid derivative of formula I ##STR1## wherein R.sub.1 is an aliphatic hydrocarbon radical that is substituted by optionally acylated or aliphatically or araliphatically etherified hydroxy, by halogen, by optionally acylated and/or aliphatically substituted amino or by an aza-, diaza-, azoxa- or oxa-cycloaliphatic radical, or is an oxacycloaliphatic hydrocarbon radical bonded via a carbon atom, or is an optionally aliphatically N-substituted or N-acylated azacycloaliphatic hydrocarbon radical, and R.sub.2 is free or esterified carboxy, and their salts exhibit NMDA-antagonistic properties and are useful as active ingredients of anticonvulsive medicaments.
REFERENCES:
patent: 4399287 (1983-08-01), Baillie et al.
patent: 4477391 (1984-10-01), Collins
patent: 4483853 (1984-11-01), Collins et al.
patent: 4657899 (1987-04-01), Rzeszotarski et al.
patent: 4761405 (1988-08-01), Rzeszotarski et al.
patent: 4776875 (1988-10-01), Loher et al.
patent: 4916125 (1990-04-01), Herrling et al.
patent: 5051413 (1991-09-01), Angst et al.
patent: 5095139 (1992-03-01), Loeffler et al.
patent: 5134134 (1992-07-01), Allgeier
Park, et al., "Structure of Plumbemycin A and B, Antagonists of L-Threonine from Streptomyces plumbeus"; Agr. Biol. Chem. 41: 573-579 (1977).
Kleinrok, et al., "Preliminary Pharmacological Investigation on 38 Aminophosphonic Acids and Their Derivatives" Pol. J. Pharma. 37:275-284 (1985).
Park, et al., "2-Amino-5-phosphono-3-pentenoic Acid, a New Amino Acid from N-1409 Substance, an Antagonist of Threonine" Agr. Biol. Chem. 40(9):1905-1906 (1976).
Allgeier Hans
Angst Christof
Heckendorn Roland
Wallach Daniel
Ciba-Geigy Corp.
Dees Jose'G.
Fishman Irving M.
Frazier B.
Ikeler Barbara J.
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