Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1995-06-07
1996-01-30
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
562 11, 562567, C07C22930, C07F 938, A61K 3166
Patent
active
054881404
ABSTRACT:
Substituted 2-aminoalk-3-enoic acid derivative of formula I ##STR1## wherein R.sub.1 is an aliphatic hydrocarbon radical that is substituted by hydroxy, and R.sub.2 is free or esterified carboxy, and their salts exhibit NMDA-antagonistic properties and are useful as active ingredients of anticonvulsive medicaments.
REFERENCES:
patent: 4399287 (1983-08-01), Baillie et al.
patent: 4469643 (1984-09-01), Tsuruoka et al.
patent: 4477391 (1984-10-01), Collins
patent: 4483853 (1984-11-01), Collins et al.
patent: 4657899 (1987-04-01), Rzeszotarski et al.
patent: 4761405 (1988-08-01), Rzeszotarski et al.
patent: 4776875 (1988-10-01), Loher et al.
patent: 4916125 (1990-04-01), Herrling et al.
patent: 5051413 (1991-09-01), Angst et al.
patent: 5095139 (1992-03-01), Loeffler et al.
patent: 5134134 (1992-07-01), Allgeier
Fagg et al "CGP 37849 and CGP 39551 Novel and Potent Competitive N-Methyl-D-Aspartate Receptor Antagonists with Oral Activity", Br. J. Pharmacol. vol. 99, 791-797 (1990).
Park et al "2-Amino 5-Phosphono-3-Pentenoic Acid A New Amino Acid from N-1409 Substance, An Antagonist of Threonine" Agr. Biol Chem. vol. 40.(9) 1905-06 (1976).
Park et al "Structure of Plumbemycin A and B, Antagonists of L-Threonine from Streptomyces plumbeus" Agr. Biol Chem. vol. 41, 573-579 (1977).
Kleinrok et al "Preliminary Pharmacological Investigation on 38 Amino Phosphonic Acids and Their Derivatives". Pol. J. Pharmacol & Phar. vol. 37: 275-284 (1985).
Allgeier Hans
Angst Christof
Heckendorn Roland
Wallach Daniel
Ciba-Geigy Corporation
Dees Jos,e G.
Frazier Barbara S.
Kaiser Karen G.
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