4-Substituted-1-piperidinesulfonamides

Details 4-Substituted-1-piperidinesulfonamides 4-Substituted-1-piperidinesulfonamides

1975-01-28

1976-03-16

Winters, Sherman D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D21126

Patent

active

039445240

ABSTRACT:
A series of novel 1-piperidinesulfonylurea compounds derived from a nitrogen-containing monocarboxylic acid have been prepared by reacting an appropriate sulfamide with an organic isocyanate or a trisubstituted urea equivalent thereof. The sulfamylureas so obtained are useful in therapy as oral hypoglycemic agents. Typical members include those compounds derived from 2-methoxynicotinic acid, of which 1-(bicyclo[2.2.1]hept-5-en-2-yl-endomethyl)-3-{4-[2-(2-methoxynicotinamido )ethyl]-1-piperidinesulfonyl}urea is a most preferred embodiment.

REFERENCES:
patent: 3105072 (1963-09-01), Felder et al.
patent: 3794652 (1974-02-01), Naito

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