4-Substituted-1,3-dithiolan-2-ylidene malonates and pharmaceutic

Details 4-Substituted-1,3-dithiolan-2-ylidene malonates and pharmaceutic 4-Substituted-1,3-dithiolan-2-ylidene malonates and pharmaceutic

1975-06-06

1977-07-05

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Cancer cell or component thereof

260327M, A61K 31385, C07D33906

Patent

active

040341020

ABSTRACT:
A 1,3-dithiolan-2-ylidene malonate derivative having the formula, ##STR1## wherein R.sup.1 and R.sup.2, which may be same or different, represent individually a C.sub.1 -C.sub.4 alkyl group; and R.sup.3 represents a chloromethyl group, a phenyl group, a group of the formula ##STR2## (where R.sup.4 and R.sup.5 represent individually a C.sub.1 -C.sub.4 alkyl group, or may form, in combination, a lower alkylene group which is sometimes intercepted by an oxygen atom), or a group of the formula ##STR3## (where M represents a hydrogen atom or a salt-foming residue; and A represents a lower alkylene group, a lower alkenylene group, a phenylene group or a cyclohexenylene group), has effects of stimulating, improving and recovering the functions of livers, and can prevent, alleviate and cure various liver damages of humans and animals when administered thereto either orally or parenterally.

REFERENCES:
patent: 3544594 (1970-12-01), Grim
patent: 3761596 (1973-09-01), Taninaka et al.
patent: 3856812 (1974-12-01), Taninaka et al.

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