Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1982-09-29
1984-12-04
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
2602393T, C07D40306
Patent
active
044865910
ABSTRACT:
Compounds are described of the formula ##STR1## or an acid addition salt thereof; in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl C.sub.1-4 alkyl, halogen, C.sub.1-4 haloalkyl, C.sub.1-4 alkanoyl, nitro, amino, C.sub.2-4 acylamino, cyano, hydroxyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 haloalkoxy or a group of the formula -SO.sub.2 N(R.sup.8).sub.2, -SO.sub.2 R.sup.8 or -SO.sub.3 R.sup.8 where R.sup.8 is C.sub.1-4 alkyl, C.sub.1-4 haloalkyl or optionally substituted phenyl; in which R.sup.5 is a group of the formula ##STR2## where R.sup.9 is hydrogen, C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, C.sub.2-4 alkenyl, C.sub.1-4 alkanoyl, benzyl, cyano or optionally substituted phenyl, where R.sup.10 is hydrogen, C.sub.1-4 alkyl or optionally substituted phenyl and where n is 0 or 1; in which R.sup.6 is hydrogen, C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, benzyl, C.sub.1-6 alkanoyl, C.sub.1-4 carbalkoxy or benzoyl; and in which R.sup.7 is one of the values of R.sup.6 or halogen, nitro, cyano, amino or C.sub.1-4 acylamino. The compounds are active as pharmaceuticals and particularly in the treatment of disorders of the central nervous system.
REFERENCES:
patent: 3450694 (1969-06-01), Swett et al.
patent: 3660380 (1972-05-01), Schmidt et al.
patent: 3743734 (1973-07-01), Schmidt et al.
patent: 3758479 (1973-10-01), Schmutz et al.
patent: 3761481 (1973-10-01), Nakanishi et al.
patent: 3951981 (1976-04-01), Safir
patent: 3953430 (1976-04-01), Safir
patent: 4115568 (1978-09-01), Chakrabarti et al.
patent: 4115574 (1978-09-01), Chakrabarti et al.
patent: 4172831 (1979-10-01), Chakrabarti et al.
patent: 4404137 (1983-09-01), Chakrabarti et al.
Rajappa et al., Indian J. Chem., 1976, 14B, 394-396.
Rajappa et al., CA85:177301e, (1976).
Schneider et al., CA80:14969m, (1974).
Plescia et al., CA92: 6514s, (1980).
Chakrabarti Jiban K.
Hotten Terrence M.
Daus Donald G.
Dow Karen B.
Gibson S. A.
Lilly Industries Limited
Whale Arthur R.
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