4-spiroindoline piperidines promote release of growth hormone

Details 4-spiroindoline piperidines promote release of growth hormone 4-spiroindoline piperidines promote release of growth hormone

1997-03-18

1999-03-09

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514255, 514256, 514278, 544 80, 544 81, 544120, 544121, 544122, 544336, 544359, 546 17, A61K 3144, A61K 31495, C07D40114, C07D40314

Patent

active

058801251

ABSTRACT:
The present invention is directed to certain novel compounds identified as 4-spiroindoline piperidines of the general structural formula: ##STR1## wherein R.sup.1, R.sup.1a, R.sup.2a, R.sup.3a, R.sup.3b, R.sup.4, R.sup.5, R.sup.8, and A are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing these compounds as the active ingredient thereof are also disclosed.

REFERENCES:
patent: 5492916 (1996-02-01), Morriello et al.
patent: 5492920 (1996-02-01), Chen et al.
patent: 5494919 (1996-02-01), Morriello et al.
patent: 5536716 (1996-07-01), Chen et al.
patent: 5559128 (1996-09-01), Chakravarty et al.
patent: 5578593 (1996-11-01), Chen et al.

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