4(R)-substituted 6(S)-phenoxymethyl-, 6(S)-.beta.-phenylethyl- a

Details 4(R)-substituted 6(S)-phenoxymethyl-, 6(S)-.beta.-phenylethyl- a 4(R)-substituted 6(S)-phenoxymethyl-, 6(S)-.beta.-phenylethyl- a

1989-03-30

1990-08-07

Russell, Mark W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514444, 514449, 514459, 514460, 514824, 549292, 549293, 549 60, 546340, 546342, A61K 31365, A61K 3144, C07B21324, C07B30708

Patent

active

049468529

ABSTRACT:
4(R)-Substituted 6(S)-phenyloxymethyl-, 6(S)-.beta.-phenylethyl- and 6(S)-.beta.-styryl-tetrahydropyran-2-ones of the general formula V ##STR1## in which R.sup.7, R.sup.8 and A have the meanings given, and the corresponding open-chain hydroxycarboxylic acids, pharmacologically acceptable salts and esters thereof, processes for the preparation of these compounds, their use as medicaments and pharmaceutical products are described. Novel .alpha.,.beta.-unsaturated lactones for the preparation of the compounds of the formula V are also described.

REFERENCES:
patent: 4255444 (1981-03-01), Oka et al.
patent: 4440927 (1984-04-01), Prugh
patent: 4661483 (1987-04-01), Hoffman et al.
patent: 4710513 (1987-12-01), Willard et al.
Bartmann et al., "Convenient Two-Step, etc." TL 27 4709.
Yang et al., "Mevinic Acids and Analogues, etc." TL 23 4305.
Japanese Abstract No. 57-7480.
Japanese Abstract No. 56-5474.
Stokker et al., J. Med. Chem., vol. 28, 1985, pp. 347-358.
Hoffman et al., J. Med. Chem., vol. 29, 1986, pp. 159-180.
A. Endo, J. Med. Chem., vol. 28, 1985, pp. 401-405.
Stokker et al., Journal of Medicinal Chemistry, vol. 29, 1986, pp. 170-181.
Hoffman et al., Journal of Medicinal Chemistry, vol. 29, No. 2, 1985, pp. 159-169.

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