4(Quinolyl)phenoxy alkanoic acid derivatives

Details 4(Quinolyl)phenoxy alkanoic acid derivatives 4(Quinolyl)phenoxy alkanoic acid derivatives

1974-03-08

1976-11-16

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260283S, 26029382, 2603261, 2603262, 26032642, 2603458, 260471A, 260473G, 424258, 424267, 424274, 424311, 424317, C07D21506, C07D21514

Patent

active

039923860

ABSTRACT:
Phenoxyacetic acids of the formula ##SPC1##
Wherein R.sub.1 is H or alkyl of 1-4 carbon atoms; R.sub.2 is H, or when R.sub.4 is Q, also alkyl of 1-4 carbon atoms; R.sub.3 is methyl, phenyl or chlorophenyl; and R.sub.4 is piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1-R.sub.5 -1,2,3,4-tetrahydro-4-quinolyl, 4-piperidinophenyl, 4-piperidinophenoxy, 1-pyrryl, or Q, wherein R.sub.5 is H or alkyl of 1-4 carbon atoms; and Q is 4-oxo-1,2,3,4-tetrahydroquinolino, 4-hydroxy-1,2,3,4-tetrahydroquinolino, 4-chromanyl, 4-thiochromanyl or 1-phenyl-1,2,3,4-tetrahydro-4-quinolyl; and the salts thereof, possess cholesterol level-lowering activity.

REFERENCES:
patent: 1974810 (1934-09-01), Duornikoff
patent: 3270024 (1966-08-01), Shapiro et al.
patent: 3299044 (1967-01-01), Cusic et al.
patent: 3804839 (1974-04-01), Dahm et al.
Oxford University Press, "Dictionary of Organic Compounds" vol. 4, p. 2663, (1965).

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