4-Quinoline and isoquinoline substituted 2,6-diamino-1,4-dihydro

Details 4-Quinoline and isoquinoline substituted 2,6-diamino-1,4-dihydro 4-Quinoline and isoquinoline substituted 2,6-diamino-1,4-dihydro

1975-01-28

1977-09-20

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260287CE, 424258, C07D21700, C07D21550

Patent

active

040496627

ABSTRACT:
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2,6-diamino-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an amidine with either an aldehyde or an ylidenecyanoacetoacetic acid ester.

REFERENCES:
patent: 2359329 (1944-10-01), Phillips et al.

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