4-Quinoline and 4-isoquinoline derivatives of 2,6-diamino-1,4-di

Details 4-Quinoline and 4-isoquinoline derivatives of 2,6-diamino-1,4-di 4-Quinoline and 4-isoquinoline derivatives of 2,6-diamino-1,4-di

1975-02-28

1977-04-05

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260287D, 260287CE, A61K 3147

Patent

active

040162770

ABSTRACT:
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2,6-diamino-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an amidine with either an aldehyde or an ylidenecyanoacetoacetic acid ester.

REFERENCES:
patent: 2359329 (1944-10-01), Phillips et al.
Harington, "Hypotensive Drugs", 1956, pp. 8, 9, 13, 35-37, 74-75, 82, 92-93, 124, 125, 193-195.
Donoso, "Drugs in Cardiology," vol. I parts 1 and 2, 1975, (1) pp. 1-2, 12, 13, 16, 70-71, (2) 1, 12, 18-19, 31, 34.
McMahon, "Cardiovascular Drugs," 1975, pp. 1-3, 22-23, 121-122.

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