4-Pyrrolidino-cyclohexanone ketals

Details 4-Pyrrolidino-cyclohexanone ketals 4-Pyrrolidino-cyclohexanone ketals

1977-10-11

1979-12-25

Tovar, Jose

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

2603265SM, 2603265S, 26032636, 2603265D, C07D29508, C07D29510, H61K 3140

Patent

active

041805844

ABSTRACT:
A class of new 4-amino-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts.
Processes for snythesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.

REFERENCES:
patent: 4065573 (1977-12-01), Daniel Lednicer

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