4-(Pyridyl, piperazinyl and thiazolyl substituted thiazolyl)-3-h

Details 4-(Pyridyl, piperazinyl and thiazolyl substituted thiazolyl)-3-h 4-(Pyridyl, piperazinyl and thiazolyl substituted thiazolyl)-3-h

1979-09-11

1981-10-20

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

546284, 548202, C07D41714, A61K 31425, A61K 3144, A61K 31495

Patent

active

042962374

ABSTRACT:
Novel 4-(substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate renal lithiasis.

REFERENCES:
patent: 3340263 (1967-09-01), Stachlein et al.
Liao et al., Arch. Biochem. Biophys., 154, pp. 68-75, (1973).
Harlay, J. Pharm. Chim., 24, pp. 537-548, (1936).
Randall et al., J. Med. Chem., 22, pp. 608-614 (1979).
G. S. Skinner et al., J. Am. Chem. Soc., 73, pp. 2230-2233, (1951).
G. S. Skinner et al., J. Am. Chem. Soc., 70, pp. 4011-4013, (1948).

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