Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2006-02-07
2006-02-07
McKenzie, Thomas C. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C544S114000, C544S224000, C544S232000, C544S239000, C544S241000, C514S085000, C514S236500, C514S247000, C514S252010, C514S252030, C514S252040, C514S252050
Reexamination Certificate
active
06995261
ABSTRACT:
Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof:whereinR1is a halogen, or an oxygen linked leaving group including an aromatic ether, an alkyl sulfonate, an aryl sulfonate, an alkyl phosphonate, an aryl phosphonate, an alkyl phosphate or aryl phosphate;R2is COOR5, C(═O)NH(CHR5)m—COOR5, NH(CHR5)mCON(R5)R6, C(═O)N(R5)R6or NH(CHR5)mOH;R3is H or alkyl;R4is H, substituted or unsubstituted aryl, heteroaryl or alkyl;R5and R6are independently H, lower alkyl, aryl, hydroxy alkyl, amino alkyl, heteroaryl, lower alkylene-aryl, lower alkylene-heteroaryl or lower cycloalkyl; and m=0–6; pharmaceutical compositions containing the compounds; and a method for inhibiting interleukin-1β protease activity in a mammal utilizing the compounds and compositions.
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Ator Mark A.
Dolle Roland E.
Hoyer Denton W.
Rinker James M.
Ross Tina Morgan
Fish & Neave IP Group Ropes & Gray LLP
Haley Jr. James F.
McKenzie Thomas C.
Shin Tae Bum
Vertex Pharmaceuticals Incorporated
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