4-(Polyalkoxyphenyl)-2-pyrrolidones

Details 4-(Polyalkoxyphenyl)-2-pyrrolidones 4-(Polyalkoxyphenyl)-2-pyrrolidones

1975-03-20

1977-03-15

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

42424858, 424250, 424267, 2602471M, 2602472A, 260246B, 260268H, 26029364, 26029371, 2603265FL, 2603265S, 26032645, 26032647, 26032637, 42424854, 42424855, 42424856, A61k 3140

Patent

active

040124959

ABSTRACT:
4-(Polyalkoxyphenyl)-2-pyrrolidones of the formula ##STR1## wherein R.sub.1 and R.sub.2 each are hydrocarbon of up to 18 carbon atoms or alkyl of 1-5 carbon atoms substituted by halogen, OH, COOH, alkoxy, alkoxycarbonyl, carboxamido or amino or collectively are alkylene of 1-3 carbon atoms, R.sub.3 is H or OCH.sub.3, R.sub.4 is H, alkyl, aryl or acyl and X is O or S possess neuropsychotropic activity. The compounds wherein X is O are produced by saponifying and decarboxylating a corresponding 2-pyrrolidone-3-carboxylic acid alkyl ester or cyclizing a corresponding 3-phenyl-4-aminobutyric acid or alkyl ester thereof. The pyrrolidones are converted to corresponding thiopyrrolidones in a conventional manner, e.g., by reaction with phosphorous pentasulfide in the presence of base.

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