4-piperidino-and piperazinomethyl-2-phenylimidazole derivatives,

Details 4-piperidino-and piperazinomethyl-2-phenylimidazole derivatives, 4-piperidino-and piperazinomethyl-2-phenylimidazole derivatives,

1995-06-05

1997-08-12

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

546 2P, 5483431, 5483435, C07D40306, C07D40304, C07D40106, C07D40104, C07D23364

Patent

active

056567626

ABSTRACT:
Disclosed are compounds of the formula: ##STR1## wherein R.sub.1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y optionally substituted nitrogen or carbon atoms; R.sub.3 and R.sub.4 are organic or inorganic substitutents which may together form ring structures; m is zero, one or two; and R.sub.5 and R.sub.6 are are organic or inorganic substituents;
and the pharmaceutically acceptable addition salts thereof, which compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.

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