4-phenylpiperidine compounds and their use

Details 4-phenylpiperidine compounds and their use 4-phenylpiperidine compounds and their use

1988-03-23

1989-07-04

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546209, 546239, 514331, A61K 31445, A61K 3141, C07D41304, C07D21128

Patent

active

048450952

ABSTRACT:
Piperidine compounds having the formula ##STR1## wherein R.sup.1 is hydrogen, (C.sub.1-6 -alkoxyaryl)alkyl, diphenylmethozy-C.sub.1-6 -alkyl, C.sub.1-8 -alkyl, C.sub.4-10 -cycloalkylalkyl, phenoxy-C.sub.1-8 -alkyl, or C.sub.1-6 -alkoxy-C.sub.1-6 -alkyl; and
R is ##STR2## or CH.dbd.NOR' wherein R' is C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl, C.sub.1-6 -alkoxy-C.sub.1-6 -alkyl, aryl-C.sub.0-6 -alkyl, which may optionally be substituted with one or more halogen and (.sub.1-5 -alkoxy, thienyl, or C.sub.4-7 -cycloalkylalkyl.
The novel compounds are useful for the treatment of pain conditions and as neuroleptics.

REFERENCES:
patent: 4016170 (1977-04-01), Nadelson

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