4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S194000, C546S209000, C546S213000

Reexamination Certificate

active

07008952

ABSTRACT:
Compounds of general formula I[Chemical formula should be inserted here. Please see paper copy] R1is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1phenyl ring and R1heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6alkyl, NO2, CF3, C1–C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

REFERENCES:
patent: 4091096 (1978-05-01), Beck et al.
patent: 4126689 (1978-11-01), Sanczuk et al.
patent: 4252812 (1981-02-01), Welch
patent: 4460586 (1984-07-01), Berthold
patent: 4680296 (1987-07-01), Manoury et al.
patent: 5118693 (1992-06-01), Toth et al.
patent: 5132303 (1992-07-01), Toth et al.
patent: 5132309 (1992-07-01), Toth et al.
patent: 5854245 (1998-12-01), Duggan et al.
patent: 6153626 (2000-11-01), Pelcman et al.
patent: 6399635 (2002-06-01), Pelcman et al.
patent: 6455545 (2002-09-01), Delorme et al.
patent: 6552036 (2003-04-01), Boyd et al.
patent: 6756387 (2004-06-01), Brown et al.
patent: 28 22 465 (1978-11-01), None
patent: 206 677 (1989-08-01), None
patent: WO 98/28270 (1998-07-01), None
patent: WP08/28275 (1998-07-01), None
patent: WO 99/33806 (1999-07-01), None
patent: WO 99/45925 (1999-09-01), None
patent: WO 0146263 (2001-06-01), None
Wei et al N, N-diethyl-4-(phenylpiperidin-4-ylidenemethyl0benzamide . . . J. of Med. Chem. 2000, 43, pp. 3895-3905.
Database ChemABS ‘Online’, CAS, Columbus, Ohio, US; 1995, Wang, et al: “Opioid.delta.receptor . . . and 4-(methoxymethyl)fentanyl”, Database Accession No. 1995:857886.
Database ChemABS ‘Online’, CAS, Columbus, Ohio, US; Deruiter, et al: “Investigation of the synthesis . . . 1-substituted 4-(propananilido)perhydroazepines”, Database Accession No. 1992:612296.
Database ChemABS ‘Online’, CAS, Columbus, Ohio, US; Ferrand, et al: “Synthesis of New 1,2,3-triazin-4-ones as Potential Antidepressants”, Database Accession No. 1988:150431.
Database ChemABS ‘Online’, CAS, Columbus, Ohio, US; Adachi, et al: “Aminohaloborane in organic synthesis. IX. Exclusive . . . N-monoaminoalkylanilines”, Database Accession No. 1987:49715.
Database ChemABS ‘Online’, CAS, Columbus, Ohio, US; Takai, et al: “ Synthesis and Pharmacological Evaluation . . . Heterocyclic Rings at the 4-position”, Database Accession No. 1985:578235.
Database ChemABS ‘Online’, CAS, Columbus, Ohio, US; Sugasawa, et al: “ 1-Azacycloalkyl-1, 4-Benzodiazepin-2-ones with antianxiety-antidepressant actions”, Database Accession No. 1985:437458.
Database ChemABS ‘Online’, CAS, Columbus, Ohio, US; Zhu, et al: “Studies on Potent Analgesics. I. Synthesis . . . Derivatives”, Database Accession No. 1981:550311.
Database ChemABS ‘Online’, CAS, Columbus, Ohio, US; Burkartsmaier, et al: “Potential analgesics. IX: Synthesis . . . acid derivatives”, Database Accession No. 1979:54780.
Database ChemABS ‘Online’, CAS, Columbus, Ohio, US; Obase, et al: “New antihypertensive agents: III Synthesis and . . . at the 4-position”, Database Accession No. 1984:120835.
Bilsky, et al., SNC 80, A Selective Nonpeptidic and Systemically Active Opioid Delta Agonist, J: Pharmacol. Experi. Ther. 273:359-366(1995).
Takemori, et al., “Selective Natrexone-Drived Opioid Receptor Antagonists,” Annu. Rev. Pharmacol. Toxicol. 32:239-269 (1992).
Enein, et al., abstract #159379n, Synthesis of some 4-substituted amino-1-methyl piperidines structurally related to antihistaminics, Chem. Abstr. 78:396 (1973).
Laskowska, abstract #105299e, “1-methyl-r-[N-phenyl-N-(2-thienyl)amino]piperidine,” Chem. Abstr. 81:510 (1974).
Podlogar, et al., “Synthesis and evalation of 4-(N,N-diarylamino)piperidines with high selectivity to the o-opioid receptor: A combined 3D-QSAR and ligand docking study,” Drug Design and Discovery, 34-50 (2000).
Sarges, et al., “Neuroleptic activity of chiral trans-hexahydro-y-carbvolines,” J. Med. Chem. 29:8-19 (1986).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3529761

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.