Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-04-04
2006-04-04
Desai, Rita (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S317000, C546S192000, C546S207000
Reexamination Certificate
active
07022715
ABSTRACT:
Compounds of general formula I: R1is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1phenyl ring and R1heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C?6? alkyl, NO2, CF3, C1–C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.
REFERENCES:
patent: 2898339 (1959-08-01), Wheeler et al.
patent: 4581171 (1986-04-01), Kennis et al.
patent: 4816586 (1989-03-01), Portoghese
patent: 4939137 (1990-07-01), Russell et al.
patent: 5140029 (1992-08-01), Kennis et al.
patent: 5574159 (1996-11-01), Chang et al.
patent: 5683998 (1997-11-01), Shibayama et al.
patent: 6187792 (2001-02-01), Delorme et al.
patent: 6455545 (2002-09-01), Delorme et al.
patent: 6552036 (2003-04-01), Boyd et al.
patent: 6556387 (2003-04-01), Misso et al.
patent: 6756387 (2004-06-01), Brown et al.
patent: WO 93/15062 (1993-08-01), None
patent: WO 97/23466 (1997-07-01), None
patent: WO 98/28275 (1998-07-01), None
patent: WO9828275 (1998-07-01), None
patent: WO 99/33806 (1999-07-01), None
patent: WO 0174804 (2001-10-01), None
patent: WO 0174806 (2001-10-01), None
Wei et al, N, N-diethyl-4-(phenylpiperidine-4-ylidenemethyl)benzamide. J. of Med. Chem. 2000, vol. 43, 3895-3905.
Bilsky, et al., SNC 80, A Selective, Nonpeptidic and Systemically Active Opioid Delta Agonist, J. Pharmacol. Experi. Ther. 273:359-366(1995).
Takemori, et al., “Selective Natrexone-Drived Opioid Receptor Antagonists,” Annu. Rev. Pharmacol. Toxicol. 32:239-269 (1992).
Barber, et al., “Antinociceptive Effects of the 5-HT Antagonist Ritanserin in Rats: Evidence for an Activation . . . in the Spinal Cord,” Neuroscience Letters 99:234-238 (1989).
Greene, “Protective Groups in Organic Synthesis,” Wiley & sons, pp. 218, 220, 232, 233, 251 (1982).
Wei, et al., “N,N-Diethyl-4-(phenylpiperidin-4-ylidenemethyl) . . . and its Analogues,” J. Med. Chem. 43:3895-3905 (2000).
Zhang, et al., “Probes for Narcotic Receptor Mediated Phenomena. 26. 1-3 Synthesis . . . Opioid Receptor Ligands,” J. Med. Chem. 42:5455-5463 (1999).
Brown William
Walpole Christopher
Wei Zhong-yong
AstraZeneca AB
Desai Rita
Legaard Paul K.
Shen David
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