4-phenyl-3-substituted 1,4-dihydropyridine esters

Details 4-phenyl-3-substituted 1,4-dihydropyridine esters 4-phenyl-3-substituted 1,4-dihydropyridine esters

1994-12-02

1998-03-24

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546321, C07D21186, A61K 31455

Patent

active

057313334

ABSTRACT:
4-Phenyl-3-substituted 1,4-dihydropyridine esters are prepared by reaction of benzaldehydes with ketoesters and enamines, if appropriate with isolation of the ylidene intermediate products, or by esterification of corresponding dihydropyridinecarboxylic acids with alcohols.
The new 4-phenyl-3-substituted 1,4-dihydropyridine esters can be employed as active compounds in medicaments for the treatment of the central nervous system, in particular as cerebral therapeutics.

REFERENCES:
patent: 3764683 (1973-10-01), Bossert et al.
patent: 3932646 (1976-01-01), Meyer et al.
patent: 4044141 (1977-08-01), Bossert et al.
patent: 4264611 (1981-04-01), Berntsson et al.
patent: 4406906 (1983-09-01), Meyer et al.
patent: 4510310 (1985-04-01), Wehinger et al.
patent: 4559350 (1985-12-01), Wehinger et al.
patent: 4568681 (1986-02-01), Wehinger et al.
patent: 4622332 (1986-11-01), Wehinger et al.
patent: 4849433 (1989-07-01), Wehinger et al.
patent: 4918076 (1990-04-01), Opitz et al.
patent: 4956361 (1990-09-01), Traber et al.
patent: 4988717 (1991-01-01), Wehinger et al.
patent: 5114946 (1992-05-01), Lawter et al.
patent: 5137889 (1992-08-01), Tamada et al.
patent: 5234935 (1993-08-01), Behner et al.
patent: 5328931 (1994-07-01), Rosen et al.
patent: 5403849 (1995-04-01), Schohe-Loop et al.
Aldrichimica Acta, vol. 18, p. 25 (1985).
Still et al. J. Org. Chem. vol. 43, No. 14, 2923, (1978).
Rampe D.R., Mutledge A., Janis R.A., Triggle D.J.: Can. Journ. Physiol. Pharmacol. vol. 65, 1452, (1987).
CA 103: 123371, 1985.
Journal of Cardiovascular Pharmacology, vol. 10, pp. 560-565 (1986).

Affiliated with

Also associated with

Rating

4-phenyl-3-substituted 1,4-dihydropyridine esters does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-phenyl-3-substituted 1,4-dihydropyridine esters, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-phenyl-3-substituted 1,4-dihydropyridine esters will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2289237