4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl...

Details 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl... 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl...

2007-05-29

2007-05-29

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S373000, C546S277400, C546S278100, C546S278400, C514S339000

Reexamination Certificate

active

11377772

ABSTRACT:
The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having the formula IwhereinW is C, CH or N, and the dotted line emanating from W indicates a bond when W is C and no bond when W is N or CH;X is CH2, O, S, CO, CS, SO or SO2; andQ is a group of formulawherein Z is a chain of 3 to 4 chain members; wherein the chain members are selected from C, CH, CH2, CO, N and NH, provided that only one of the chain members may be N or NH, and said chain optionally containing one or two double bonds;provided that X is not O or S when the group Q is attached via an N atom;and any of its enantiomers and acid addition salts thereof.These compounds have high affinity for D4receptors.

REFERENCES:
patent: 3135794 (1964-06-01), Archer
patent: 3188313 (1965-06-01), Archer
patent: 3468882 (1969-09-01), Laskowski
patent: 4950664 (1990-08-01), Goldberg
patent: 5010079 (1991-04-01), Manoury et al.
patent: 5418237 (1995-05-01), Böttcher et al.
patent: 5556857 (1996-09-01), Oshiro et al.
patent: 5916923 (1999-06-01), Rudolph et al.
patent: 6355644 (2002-03-01), Zhao et al.
patent: 0 354 094 (1991-12-01), None
patent: 0 496 222 (1992-01-01), None
patent: 1.551.082 (1968-12-01), None
patent: 1 326 833 (1973-08-01), None
patent: 94/24105 (1994-10-01), None
patent: 98/08816 (1998-03-01), None
patent: 99/09025 (1999-02-01), None
Srinivas et al. Pharm.Pharmacol.Commun. vol. 5, p. 95-101 (1999).
Zhao et al. Bioorganic & Medicinal Chemistry Letters, vol. 12, p. 3105-3109 (Nov. 2002).
El-Gendy et al. Chemical Abstracts, vol. 117, No. 90076 (1992).
Bourdals, Chemical Abstracts, vol. 78, No. 97706 (1973).
Leurquin et al. Chemical Abstracts, vol. 76, No. 144827 (1972).
Bourdais, Chemical Abstracts, vol. 74, No. 125324 (1971).
CAS printout for Havera et al., Chem Abstract 73:109705.
CAS printout for Archer et al., Chem Abstract 61: 25461.
CAS printout for Alter et al., Chem Abstract 60:45777.
Jardemark et al. Dopamine D3 and D4 receptor antagonists in the treatment of schizophrenia, Curr. Opin. Invest. Drugs, 3:101-105. 2002.
Mokrosz, M.J. et al., “5-HT1Aand 5-HT2Areceptor affinity and functional profile of someN-[3-(4-aryl-1-piperazinyl)propyl] derivatives of indolin-2(1H)-one, quinolin-2(1H)-one and isoquinolin-1(2H)-one,”Pharmazie 52, 1997, 6:423-428.
Böttcher, Henning et al., “Synthesis and Dopaminergic Activity of Some 3-(1,2,3,6-Tetrahydro-1-pyridylalkyl)indoles. A Novel Conformational Model to Explain Structure Activity Relationships,”J. Med. Chem., 1992, 35:4020-4026.
Misztal, Stanislaw et al., “Synthesis and Pharmacological Properties of N-Arylpiperazine-N′-Alkylindanes,”Pol. J. Pharmacol. Pharm., 1984, 36:697-703.

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