4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl...

Details 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl... 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl...

2006-07-11

2006-07-11

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S373000, C544S363000, C544S392000, C514S253050, C514S253060, C514S253070, C514S255030, C514S307000, C514S311000, C514S312000, C514S323000, C546S146000, C546S150000, C546S158000, C546S168000, C546S176000, C546S201000

Reexamination Certificate

active

07074796

ABSTRACT:
The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having the formula Iwherein W is C, CH or N, and the dotted line emanating from W indicates a bond when W is C and no bond when W is N or CH;R1and R2are independently selected from hydrogen and halogen, provided at least one of R1and R2is a halogen atom;R3is selected from hydrogen, halogen, C1-6alkyl, trifluoromethyl, C1-6alkoxy, aryloxy, aralkoxy, hydroxy, amino, C1-6alkylamino, di(C1-6alkyl)amino, nitro and cyanon is 2, 3, 4 or 5;X is CH2, O, S, CO, CS, SO or SO2; andQ is a group of formulawherein Z is a chain of 3 to 4 chain members; wherein the chain members are selected from C, CH, CH2, CO, N and NH, provided that only one of the chain members may be N or NH, and said chain optionally containing one or two double bonds; hvad med acyl??R4, R5, R6, R7, R8, R9and R10are independently selected from hydrogen, halogen, C1-6alkyl, trifluoromethyl, C1-6alkoxy, hydroxy, amino, C1-6alkylamino, di(C1-6alkyl)amino nitro and cyano;provided that X is not O or S when the group Q is attached via an N atom;and any of its enantiomers and acid addition salts thereof.These compounds have high affinity for D4receptors.

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