Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-11-09
1987-05-26
Chan, Nicky
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549375, 549370, 549362, 549350, 549342, 549332, 514450, A61K 31335, C07D31906
Patent
active
046686983
ABSTRACT:
The invention concerns novel [(4-phenyl-1,3-dioxan-cis-5-yl)alkyl]phenylalkanoic acids of the formula I wherein Ra and Rb are a variety of substituents including alkyl, alkenyl, halogenoalkyl, phenyl and benzyl, or together form polymethylene; Rc is hydroxy, alkoxy or alkanesulphonamido; A.sup.1 and A.sup.2 are polymethylene; X is oxygen, sulphur or a direct bond; and benzene ring A bears a variety of substituents; and, when Rc is hydroxy, the physiologically acceptable salts thereof. The compounds of formula I are thromboxane antagonists of value in treating a variety of disease conditions. The invention also provides processes for the manufacture of, and pharmaceutical compositions of, the compounds of formula I.
REFERENCES:
patent: 2500155 (1950-03-01), Croxall et al.
patent: 2992234 (1961-07-01), Acker et al.
J. Fried et al, "Advances in Prostaglandin and Thromboxane Research", vol. 6, pp. 427-436, Raven Press, N.Y., 1980.
Chan Nicky
Imperial Chemical Industries plc
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